[HTML][HTML] White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

AJ Burns, AM Goldstein, DF Newgreen, L Stamp… - Developmental …, 2016 - Elsevier
Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

Building a second brain in the bowel

M Avetisyan, EM Schill… - The Journal of clinical …, 2015 - Am Soc Clin Investig
The enteric nervous system (ENS) is sometimes called the “second brain” because of the
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …

Neural stem cell therapies for enteric nervous system disorders

AJ Burns, N Thapar - Nature reviews Gastroenterology & hepatology, 2014 - nature.com
The enteric nervous system is vulnerable to a range of congenital and acquired disorders
that disrupt the function of its neurons or lead to their loss. The resulting enteric neuropathies …

Optogenetic demonstration of functional innervation of mouse colon by neurons derived from transplanted neural cells

LA Stamp, RM Gwynne, JPP Foong, AE Lomax… - Gastroenterology, 2017 - Elsevier
Background & Aims Cell therapy offers the potential to treat gastrointestinal motility disorders
caused by diseased or absent enteric neurons. We examined whether neurons generated …

Isolation of enteric nervous system progenitor cells from the aganglionic gut of patients with Hirschsprung's disease

DJ Wilkinson, GS Bethell, R Shukla, SE Kenny… - PloS one, 2015 - journals.plos.org
Enteric nervous system progenitor cells isolated from postnatal human gut and cultured as
neurospheres can then be transplanted into aganglionic gut to restore normal patterns of …

Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies

E Binder, D Natarajan, J Cooper, R Kronfli, M Cananzi… - PloS one, 2015 - journals.plos.org
Objectives Enteric neural stem cells provide hope of curative treatment for enteric
neuropathies. Current protocols for their harvesting from humans focus on the generation of …

Exposure to GDNF enhances the ability of enteric neural progenitors to generate an enteric nervous system

SJ McKeown, M Mohsenipour, AJ Bergner, HM Young… - Stem cell reports, 2017 - cell.com
Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat
enteric neuropathies. However, for translation to the clinic, it is highly likely that enteric …

[HTML][HTML] Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays

D Seidel, J Obendorf, B Englich, HG Jahnke… - Biosensors and …, 2016 - Elsevier
In today's neurodevelopment and-disease research, human neural stem/progenitor cell-
derived networks represent the sole accessible in vitro model possessing a primary …

Retinoic acid accelerates the specification of enteric neural progenitors from in-vitro-derived neural crest

TJR Frith, A Gogolou, JOS Hackland, ZA Hewitt… - Stem cell reports, 2020 - cell.com
The enteric nervous system (ENS) is derived primarily from the vagal neural crest, a
migratory multipotent cell population emerging from the dorsal neural tube between somites …

Development of circadian oscillators in neurosphere cultures during adult neurogenesis

A Malik, RJ Jamasbi, RV Kondratov, ME Geusz - PloS one, 2015 - journals.plos.org
Circadian rhythms are common in many cell types but are reported to be lacking in
embryonic stem cells. Recent studies have described possible interactions between the …