Scattering-based light microscopy: from metal nanoparticles to single proteins

L Priest, JS Peters, P Kukura - Chemical reviews, 2021 - ACS Publications
Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Interferometric scattering microscopy: seeing single nanoparticles and molecules via Rayleigh scattering

RW Taylor, V Sandoghdar - Nano letters, 2019 - ACS Publications
Fluorescence microscopy has been the workhorse for investigating optical phenomena at
the nanometer scale but this approach confronts several fundamental limits. As a result …

Operando optical tracking of single-particle ion dynamics in batteries

AJ Merryweather, C Schnedermann, Q Jacquet… - Nature, 2021 - nature.com
The key to advancing lithium-ion battery technology—in particular, fast charging—is the
ability to follow and understand the dynamic processes occurring in functioning materials …

Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review

W Zhang, R Taheri-Ledari, F Ganjali… - RSC …, 2023 - pubs.rsc.org
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers
are of great importance and need to be discussed in depth. To be concise, among all the …

Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane

RW Taylor, RG Mahmoodabadi, V Rauschenberger… - Nature …, 2019 - nature.com
Many of the biological functions of a cell are dictated by the intricate motion of proteins within
its membrane over a spatial range of nanometres to tens of micrometres and time intervals of …

Interferometric scattering microscopy

G Young, P Kukura - Annual review of physical chemistry, 2019 - annualreviews.org
Interferometric scattering microscopy (iSCAT) is an extremely sensitive imaging method
based on the efficient detection of light scattered by nanoscopic objects. The ability to, at …

Label-free imaging of DNA interactions with 2D materials

J Sulzle, W Yang, Y Shimoda, N Ronceray… - ACS …, 2024 - ACS Publications
Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their
properties can be engineered to tune interactions between the surface and biomolecules …

Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity

N Goswami, YR He, YH Deng, C Oh, N Sobh… - Light: Science & …, 2021 - nature.com
Efforts to mitigate the COVID-19 crisis revealed that fast, accurate, and scalable testing is
crucial for curbing the current impact and that of future pandemics. We propose an optical …

Particle tracking of nanoparticles in soft matter

KA Rose, M Molaei, MJ Boyle, D Lee… - Journal of Applied …, 2020 - pubs.aip.org
Recent advances in optical microscopy instrumentation and processing techniques have led
to imaging that both breaks the diffraction barrier and enables sub-pixel resolution. This …

Point spread function in interferometric scattering microscopy (iSCAT). Part I: aberrations in defocusing and axial localization

R Gholami Mahmoodabadi, RW Taylor, M Kaller… - Optics …, 2020 - opg.optica.org
Interferometric scattering (iSCAT) microscopy is an emerging label-free technique optimized
for the sensitive detection of nano-matter. Previous iSCAT studies have approximated the …