The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Summary The c-Myc HLH-bZIP protein has been implicated in physiological or pathological
growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or …

MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

Quantitative measurement of transcription rates in live cells is important for revealing
mechanisms of transcriptional regulation. This is particularly challenging when measuring …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

Although microRNAs (miRNAs) are key regulators of gene expression in normal human
physiology and disease, transcriptional regulation of miRNAs is poorly understood, because …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

Cellular senescence is characterized by a decrease in protein synthesis, although the
underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) …

RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs)
important for translational capacity and other functions. We localized Pol III, alternative TFIIIB …