R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …

Break-induced replication (BIR) is mutagenic, and thus its use requires tight regulation, yet
the underlying mechanisms remain elusive. Here we uncover an important role of 53BP1 in …

Common fragile sites (CFSs) are regions prone to chromosomal rearrangements, thereby
contributing to tumorigenesis. Under replication stress (RS), CFSs often harbor under …

The WRN protein is vital for managing perturbed replication forks. Replication Protein A
strongly enhances WRN helicase activity in specific in vitro assays. However, the in vivo …

G-Quadruplexes are the four-stranded non-canonical nucleic acid secondary structures,
formed by the stacking arrangement of the guanine tetramers. They are involved in a wide …

The primary role of break-induced replication (BIR) is to repair single-ended double strand
breaks (seDSBs) generated at broken replication forks and eroding telomeres. In this study …

Human RAD52 is a prime target for synthetical lethality approaches to treat cancers with
deficiency in homologous recombination. Among multiple cellular roles of RAD52, its …

Genome maintenance and stability rely on the repair of DNA double-strand breaks. The
break repair can be mediated by the single-strand annealing protein RAD52. RAD52 forms …

RESUMO O câncer é uma das principais causas de mortalidade global, representando um
desafio significativo para a saúde pública e a expectativa de vida. As células cancerígenas …