Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

The exocrine pancreas is the organ with the highest level of protein synthesis in the adult—
each day the pancreas produces litres of fluid filled with enzymes that are capable of …

Extensive genetic studies of chronic pancreatitis over the past decade have highlighted the
importance of a tightly regulated balance between activation and inactivation of trypsin …

Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …

The relationship between inflammation and proteolytic activation in pancreatitis is an
unresolved issue in pancreatology. The purpose of this study was to define the influence of …

Food protein hydrolysis, a crucial step in digestion, is catalyzed by trypsin enzymes from the
digestive apparatus of invertebrates. Trypsin appeared early in evolution and occurs in all …

Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen
have been conclusively associated with autosomal dominant hereditary pancreatitis and …

Chronic pancreatitis (CP) is a persistent inflammation of the pancreas. Over the past 12
years, genetic studies of hereditary, familial, and idiopathic forms of CP have made great …

Endoplasmic reticulum (ER) stress mechanisms have been found to play critical roles in a
number of diseases states, such as diabetes mellitus and Alzheimer disease, but whether …

Mutations in human cationic trypsinogen (PRSS1) cause autosomal dominant hereditary
pancreatitis. Increased intrapancreatic autoactivation of trypsinogen mutants has been …