With the advent of volumetric EM techniques, large connectomic datasets are being created,
providing neuroscience researchers with knowledge about the full connectivity of neural …

Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally
and functionally diverse, they accomplish a central role in determining the delays and …

Plasticity of myelination represents a mechanism to tune the flow of information by balancing
functional requirements with metabolic and spatial constraints. The auditory system is …

The axon initial segment (AIS) serves as the site of action potential initiation in most
neurons, but difficulties in isolating the effects of voltage-gated ion channels in the AIS from …

Neurons in the medial superior olive (MSO) detect microsecond differences in the arrival
time of sounds between the ears (interaural time differences or ITDs), a crucial binaural cue …

The ongoing activity of neurons generates a spatially and time-varying field of extracellular
voltage (V e). This V e field reflects population-level neural activity, but does it modulate …

In mammals with good low-frequency hearing, the medial superior olive (MSO) computes
sound location by comparing differences in the arrival time of a sound at each ear, called …

Interaural time differences (ITDs) are a major cue for sound localization and change with
increasing head size. Since the barn owl's head width more than doubles in the month after …

Neurons in the medial superior olive (MSO) detect 10 µs differences in the arrival times of a
sound at the two ears. Such acuity requires exquisitely precise integration of binaural …

Passive and active membrane properties determine the voltage responses of neurons.
Within the auditory brain stem, refinements in these intrinsic properties during late postnatal …