Feature extraction approaches for biological sequences: a comparative study of mathematical features

RP Bonidia, LDH Sampaio… - Briefings in …, 2021 - academic.oup.com
As consequence of the various genomic sequencing projects, an increasing volume of
biological sequence data is being produced. Although machine learning algorithms have …

[HTML][HTML] CRISPR-based approaches for the high-throughput characterization of long non-coding RNAs

J Hazan, AC Bester - Non-coding RNA, 2021 - mdpi.com
Over the last decade, tens of thousands of new long non-coding RNAs (lncRNAs) have been
identified in the human genome. Nevertheless, except for a handful of genes, the genetic …

SyntDB: defining orthologues of human long noncoding RNAs across primates

O Bryzghalov, MW Szcześniak… - Nucleic acids …, 2020 - academic.oup.com
Abstract SyntDB (http://syntdb. amu. edu. pl/) is a collection of data on long noncoding RNAs
(lncRNAs) and their evolutionary relationships in twelve primate species, including humans …

[HTML][HTML] Long non‑coding RNA SNHG1 relieves microglia activation by downregulating miR‑329‑3p expression in an in vitro model of cerebral infarction

J He, X Xuan, M Jiang, J Li, N Li… - Experimental and …, 2021 - spandidos-publications.com
Following cerebral infarction, activated microglia cells can release a large amount of
inflammatory cytokines, thereby exacerbating neuronal damage. It has been demonstrated …

A chromatin-associated splicing isoform of OIP5-AS1 acts in cis to regulate the OIP5 oncogene

E Wanowska, M Kubiak, I Makałowska… - RNA biology, 2021 - Taylor & Francis
ABSTRACT A large portion of the human genome is transcribed into long noncoding RNAs
that can range from 200 nucleotides to several kilobases in length. The number of identified …

[HTML][HTML] lncEvo: automated identification and conservation study of long noncoding RNAs

O Bryzghalov, I Makałowska, MW Szcześniak - BMC bioinformatics, 2021 - Springer
Abstract Background Long noncoding RNAs represent a large class of transcripts with two
common features: they exceed an arbitrary length threshold of 200 nt and are assumed to …

[HTML][HTML] LBX2-AS1 as a novel diagnostic biomarker and therapeutic target facilitates multiple myeloma progression by enhancing mRNA stability of LBX2

H Jia, Y Liu, S Lv, R Qiao, X Zhang, F Niu… - Frontiers in Molecular …, 2021 - frontiersin.org
Objective: Multiple myeloma (MM) represents a common age-associated malignancy
globally. The function and underlying mechanism of antisense lncRNA LBX2-AS1 remain …

[HTML][HTML] The Haoqin-Huaban formula alleviates UVB-induced skin damage through HOXA11-AS-mediated stabilization of EZH2

X Xu, S Wang, D Zhou, J Qu, C Zhang… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Exposure of skin to ultraviolet B (UVB) irradiation induces oxidative damage, immune
suppression, inflammation, and skin cancer. Recently, an increase in the use of traditional …

5'extended protein-coding INO80E transcript regulates expression of two head-to-head overlapping genes: INO80E and HIRIP3

N Ryczek, A Lys, E Wanowska, J Kozlowska-Maslon… - bioRxiv, 2023 - biorxiv.org
The INO80E gene encodes the protein involved in the chromatin remodeling processes as a
part of the multi-subunit INO80-chromatin remodeling complex. The INO80E gene is located …

Accumulation of lncRNAs in cytoplasm upon DIS3 depletion leads to production of cryptic peptides detected in Multiple Myeloma.

D Foretek, M Gabriel, I Hatin, J Jarroux, M Pinskaya… - 2024 - researchsquare.com
Some long noncoding (lnc) RNAs harbor the potential to produce functional micropeptides.
Despite the increasing recognition of their significance, the regulatory dynamics of …