Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences

HHA Thorpe, S Hamidullah, BW Jenkins… - Pharmacology & …, 2020 - Elsevier
Adolescence is the transitional period between childhood and adulthood, during which
extensive brain development occurs. Since this period also overlaps with the initiation of …

[HTML][HTML] Age-related differences in the impact of cannabis use on the brain and cognition: a systematic review

C Gorey, L Kuhns, E Smaragdi, E Kroon… - European archives of …, 2019 - Springer
The impact of cannabis on the adolescent compared to adult brain is of interest to
researchers and society alike. From a theoretical perspective, adolescence represents a …

Is the adolescent brain at greater vulnerability to the effects of cannabis? A narrative review of the evidence

G Blest-Hopley, M Colizzi, V Giampietro… - Frontiers in …, 2020 - frontiersin.org
Cannabis use during the critical neurodevelopmental period of adolescence, may lead to
brain structural, functional, and histological alterations that may underpin some of the longer …

THC and CBD: villain versus hero? Insights into adolescent exposure

N Pintori, F Caria, MA De Luca, C Miliano - International Journal of …, 2023 - mdpi.com
Cannabis is the most used drug of abuse worldwide. It is well established that the most
abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and …

Acute cannabinoids produce robust anxiety-like and locomotor effects in mice, but long-term consequences are age-and sex-dependent

CR Kasten, Y Zhang, SL Boehm - Frontiers in behavioral …, 2019 - frontiersin.org
The rise in cannabinoid legalization and decriminalization in the US has been paired with
an increase in adolescents that perceive marijuana as a “no risk” drug. However, a …

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

BJ Yadav-Samudrala, BL Gorman… - Frontiers in …, 2024 - frontiersin.org
Background Some evidence suggests that cannabidiol (CBD) has potential to help alleviate
HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined …

Cannabinoids, interoception, and anxiety

AK Andrade, B Renda, JE Murray - Pharmacology Biochemistry and …, 2019 - Elsevier
The use of cannabis is rapidly gaining legal status across North America. Such dramatic
legislative shifts have prompted an urgency in elucidating the stimulus effects of cannabis …

Effects of Δ9-THC and Type-1 Cannabinoid Receptor Agonists in the Elevated Plus Maze Test of Anxiety: A Systematic Review and Meta-Analysis

LP Iglesias, L Bedeschi, DC Aguiar, L Asth… - Cannabis and …, 2023 - liebertpub.com
Δ9-THC (the main active compound from Cannabis sativa) and related cannabinoids have
been used as drugs of abuse and as medications. They induce a complex set of emotional …

FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in …

SL Penman, NM Roeder, EC Berthold… - Pharmacology …, 2023 - Elsevier
Fatty acid binding protein 5 (FABP5) interacts with the endocannabinoid system in the brain
via intracellular transport of anandamide, as well as Δ9-tetrahydrocannabinol (THC), the …