The sympathetic nervous system in development and disease

E Scott-Solomon, E Boehm, R Kuruvilla - Nature Reviews …, 2021 - nature.com
The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …

The CD40-ATP-P2X7 Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells

CS Subauste - Frontiers in immunology, 2019 - frontiersin.org
Extracellular adenosine 5′-triphosphate (ATP) functions not only as a neurotransmitter but
is also released by non-excitable cells and mediates cell–cell communication involving glia …

IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective …

Y Suzuki, J Lutshumba, KC Chen… - Frontiers in Cellular …, 2023 - frontiersin.org
We previously demonstrated that brain-resident cells produce IFN-γ in response to
reactivation of cerebral infection with Toxoplasma gondii. To obtain an overall landscape …

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation

SV Hegarty, SL Wyatt, L Howard, E Stappers… - Scientific reports, 2017 - nature.com
Neural connectivity requires neuronal differentiation, axon growth, and precise target
innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the …

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation

GW O'Keeffe, H Gutierrez, L Howard, CW Laurie… - Neural …, 2016 - Springer
Background Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor
required for sympathetic neuron survival and for the growth and ramification of sympathetic …

CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons

P Carriba, AM Davies - Elife, 2017 - elifesciences.org
Dendrite size and morphology are key determinants of the functional properties of neurons
and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is …

[HTML][HTML] TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo

TG McWilliams, L Howard, S Wyatt, AM Davies - Experimental Neurology, 2017 - Elsevier
We have studied the role of the tumor necrosis factor superfamily member APRIL in the
development of embryonic mouse midbrain dopaminergic neurons in vitro and in vivo. In …

What neurons tell themselves: autocrine signals play essential roles in neuronal development and function

KA Herrmann, HT Broihier - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Activity-dependent autocrine signals play critical roles in synaptic
plasticity.•Transient retrograde signals can activate sustained autocrine signals.•Drosophila …

CD40 forward signalling is a physiological regulator of early sensory axon growth

L Howard, TG McWilliams, S Wyatt… - Development, 2019 - journals.biologists.com
Multiple members of the tumour necrosis factor superfamily (TNFSF) regulate the growth and
branching of neural processes late in development, when neurons are establishing and …

TWE-PRIL reverse signalling suppresses sympathetic axon growth and tissue innervation

L Howard, E Wosnitzka, D Okakpu, MA White… - …, 2018 - journals.biologists.com
ABSTRACT TWE-PRIL is a naturally occurring fusion protein of components of two TNF
superfamily members: the extracellular domain of APRIL; and the intracellular and …