Multi-scale modelling and simulation in systems biology
The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …
biological functions are recognised as a result of complex mechanisms that happen at …
Zonation of hepatic fatty acid metabolism—the diversity of its regulation and the benefit of modeling
J Schleicher, C Tokarski, E Marbach… - … et Biophysica Acta (BBA …, 2015 - Elsevier
A pronounced heterogeneity between hepatocytes in subcellular structure and enzyme
activities was discovered more than 50 years ago and initiated the idea of metabolic …
activities was discovered more than 50 years ago and initiated the idea of metabolic …
[图书][B] Your digital afterlives: Computational theories of life after death
E Steinhart - 2014 - books.google.com
Digitalism is a philosophical strategy that uses new computational ways of thinking to
develop naturalistic but meaningful ways of thinking about bodies, souls, universes, gods …
develop naturalistic but meaningful ways of thinking about bodies, souls, universes, gods …
A liver-centric multiscale modeling framework for xenobiotics
We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen
pharmacology and metabolism. We focus on a computational model to characterize whole …
pharmacology and metabolism. We focus on a computational model to characterize whole …
At the biological modeling and simulation frontier
We provide a rationale for and describe examples of synthetic modeling and simulation
(M&S) of biological systems. We explain how synthetic methods are distinct from familiar …
(M&S) of biological systems. We explain how synthetic methods are distinct from familiar …
Modeling of xenobiotic transport and metabolism in virtual hepatic lobule models
Computational models of normal liver function and xenobiotic induced liver damage are
increasingly being used to interpret in vitro and in vivo data and as an approach to the de …
increasingly being used to interpret in vitro and in vivo data and as an approach to the de …
Tissue‐level modeling of xenobiotic metabolism in liver: an emerging tool for enabling clinical translational research
MG Lerapetritou, PG Georgopoulos… - Clinical and …, 2009 - Wiley Online Library
This review summarizes some of the recent developments and identifies critical challenges
associated with in vitro and in silico representations of the liver and assesses the …
associated with in vitro and in silico representations of the liver and assesses the …
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms
AK Smith, GEP Ropella, MR McGill… - PLoS computational …, 2020 - journals.plos.org
Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced
liver injury often assume that the biomarker is released passively from dying cells. However …
liver injury often assume that the biomarker is released passively from dying cells. However …
Competing mechanistic hypotheses of acetaminophen-induced hepatotoxicity challenged by virtual experiments
AK Smith, BK Petersen, GEP Ropella… - PloS computational …, 2016 - journals.plos.org
Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in
humans. A precondition for improved strategies to disrupt and/or reverse the damage is a …
humans. A precondition for improved strategies to disrupt and/or reverse the damage is a …
Essential operating principles for tumor spheroid growth
Background Our objective was to discover in silico axioms that are plausible representations
of the operating principles realized during characteristic growth of EMT6/Ro mouse …
of the operating principles realized during characteristic growth of EMT6/Ro mouse …