Drosophila as a Model for Infectious Diseases

JM Harnish, N Link, S Yamamoto - International journal of molecular …, 2021 - mdpi.com
The fruit fly, Drosophila melanogaster, has been used to understand fundamental principles
of genetics and biology for over a century. Drosophila is now also considered an essential …

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

J van de Leemput, Z Han - Molecular and cellular biology, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic, responsible for millions of deaths globally. Even with effective vaccines, SARS …

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

J Zhu, G Wang, X Huang, H Lee, JG Lee… - Communications …, 2022 - nature.com
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated
with cardiovascular complications including long-term outcomes. The presence of virus in …

Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2

J van de Leemput, Z Han - Cell & Bioscience, 2021 - Springer
The COVID-19 pandemic is having a tremendous impact on humanity. Although COVID-19
vaccines are showing promising results, they are not 100% effective and resistant mutant …

Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster

T Duarte, FB Omage, GS Rieder, JBT Rocha… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Responsible for COVID-19, SARS-CoV-2 is a coronavirus in which contagious
variants continue to appear. Therefore, some population groups have demonstrated greater …

State-of-the-art strategies to prioritize Mycobacterium tuberculosis drug targets for drug discovery using a subtractive genomics approach

A Akinnuwesi, S Egieyeh, R Cloete - Frontiers in Drug Discovery, 2023 - frontiersin.org
Tuberculosis remains one of the causes of death from a single infectious bacterium. The
inappropriate use of antibiotics and patients' non-compliance among other factors drive the …

Inbreeding-Driven Innate Behavioral Changes in Drosophila melanogaster

A Amanullah, S Arzoo, A Aslam, IW Qureshi, M Hussain - Biology, 2023 - mdpi.com
Simple Summary Inbreeding includes mating between two closely related individuals. It is
known to affect the biological fitness of plants and animals, including humans. Experiments …

[图书][B] A case study on the ecosystem for local production of pharmaceuticals, vaccines, and biologicals: the Nigeria context

World Health Organization - 2024 - books.google.com
The Local Production and Assistance (LPA) Unit in the Regulation and Prequalification
Department (RPQ), Access to Medicines and Health Products Division (MHP), WHO …

[HTML][HTML] SARS-CoV-2 Nsp6 causes cardiac defects through MGA/MAX complex-mediated increased glycolysis

J Zhu, G Wang, X Huang, H Lee, J Lee, P Yang… - 2022 - europepmc.org
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated
with cardiovascular complications including long-term outcomes. The presence of virus in …

Experimental use of Drosophila to Model Proliferation of SARS-CoV-2 Infected Cells

V Wicks - 2021 - digitalcommons.liu.edu
Drosophila have been vectors for scientific research since the beginning of the 20th century.
Their successful use within experiments that investigated mendelian genetics inspired their …