Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because
they can be activated by small depolarizations of the plasma membrane. In many neurons …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

The generation of the mammalian heartbeat is a complex and vital function requiring
multiple and coordinated ionic channel activities. The functional role of low-voltage activated …

Capacitative Ca2+ entry (CCE) through store-operated Ca2+ (SOC) channels plays an
important role in returning Ca2+ to the sarcoplasmic reticulum (SR) and regulating cytosolic …

Low-threshold (T-type) Ca2+ channels encoded by the CaV3 genes endow neurons with
oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement …

1 The cellular mechanisms governing cardiac atrial pacemaker activity are not clear. In the
present study we used perforated patch voltage clamp and confocal fluorescence …