Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all
progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide …

RY rheostat, whereas AMPK discerns the balance between ATP and AMP in the cytosol.
Importantly, SIRT1 and AMPK are activated not only by fasting but also by a broad range of …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of
renal survival. Many different cell types contribute to TIF progression including tubular …

Diabetic nephropathy (DN) has become a major cause of end-stage renal disease, and
autophagy disorder is implicated in the pathogenesis of DN. Our previous studies found that …

Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …