Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Both appropriate DNA methylation and histone modifications play a crucial role in the
maintenance of normal cell function and cellular identity. In cancerous cells these …

RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

RNA-binding protein HuR binds U-or AU-rich sequences in the 3′-untranslated regions of
target mRNAs, stabilizing them and/or modulating their translation. Given the links of HuR …

Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in
patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα …