Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …

Aberrant placental angiogenesis is associated with fetal intrauterine growth restriction
(IUGR), but the mechanism underlying abnormal placental angiogenesis remains largely …

Reactive oxygen species (ROS) have been shown or at least suggested to play an essential
role for cellular signaling as second messengers. NADPH oxidases represent a source of …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

Significance: The oxidative stress, resulting from an imbalance in the production and
scavenging of reactive oxygen species (ROS), is known to be involved in the development …

Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's
disease (PD) pathogenesis and there is evidence that mitochondrially-generated …

Abstract Significance: Highly prevalent in Western cultures, obesity, metabolic syndrome,
and diabetes increase the risk of cardiovascular morbidity and mortality and cost health care …