One of the main challenges in the development of bioprocesses based on cell transient
expression is the commonly reported reduction of cell specific productivity at increasing cell …

Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

The need for new safe and efficacious therapies has led to an increased focus on biologics
produced in mammalian cells. The human cell line HEK293 has bio-synthetic potential for …

Raman spectrum based predictive models provide a process analytical technology (PAT)
tool for monitoring and control of culture parameters in bioprocesses. Steady-state perfusion …

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess
(ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to …

A continuous integrated bioprocess available from the earliest stages of process
development allows for an easier, more efficient and faster development and …

The N-linked glycosylation pattern is an important quality attribute of therapeutic
glycoproteins. It has been reported by our group and by others that different carbon sources …

We present a proof‐of‐concept study for production of a recombinant vesicular stomatitis
virus (rVSV)‐based fusogenic oncolytic virus (OV), rVSV‐Newcastle disease virus (NDV), at …

Retroviral vectors derived from murine leukemia virus (MLV) are used in somatic gene
therapy applications eg for genetic modification of hematopoietic stem cells. Recently, we …

A novel approach of design of experiment (DoE) is developed for the optimization of key
substrates of the culture medium, amino acids, and sugars, by utilizing perfusion …