Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …

Strategies based on activating GLP-1 receptor (GLP-1R) are intensively developed for the
treatment of type 2 diabetes. The exhaustive knowledge of the signaling pathways linked to …

Pancreatic β‐cells exposed to high glucose concentrations display altered gene expression,
function, survival and growth that may contribute to the slow deterioration of the functional β …

Aims/hypothesis Inadequate chaperone function relative to client protein load in the
endoplasmic reticulum triggers an adaptive unfolded protein response (UPR), including the …

The type 1 parathyroid hormone receptor (PTHR1) binds, with equal affinity, two ligands with
distinct biological functions: PTH, the major peptide hormone controlling calcium …

Pancreatic β-cells are susceptible to reactive oxygen species (ROS), which are known to be
generated by high or low glucose (LG), hypoxic, or cytokine-producing conditions. When we …

Glucose-responsive insulin delivery systems, which can maintain a stable level of blood
glucose, have been proposed as a promising method to treat diabetes. Such systems can …

For many years, feed-borne mycotoxin contamination has been a serious and unavoidable
problem in the aquaculture industry. This problem is extensively aggravated due to the …

cAMP-responsive element–binding protein (CREB) is required for β-cell survival by
regulating expression of crucial genes such as bcl-2 and IRS-2. Using MIN6 cells and …