Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and
a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in …

Substantial evidence has supported the role of endothelial cell (EC) activation and
dysfunction in the development of hypertension, chronic kidney disease (CKD), and lupus …

The actions of immune cells within the kidney are of fundamental importance in kidney
homeostasis and disease. In disease settings such as acute kidney injury, anti-neutrophil …

Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria
in many systemic and localized vascular disorders. Among them are the thrombotic …

Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the
underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely …

Acute hemorrhage commonly leads to coagulopathy and organ dysfunction or failure.
Recent evidence suggests that damage to the endothelial glycocalyx contributes to these …

Alport syndrome (AS) is a genetic disorder caused by mutations in type IV collagen that lead
to defective glomerular basement membrane, glomerular filtration barrier (GFB) damage …

Methods: In the present study, we used a rat model of hemorrhagic shock and resuscitation
to more comprehensively assess glycocalyx disruption across a range of organs. Glycocalyx …

Lupus nephritis (LN) is a common and severe manifestation of systemic lupus
erythematosus and an important cause of acute and chronic kidney injury. Early diagnosis of …

ABSTRACT Dual endothelin-1 (ET-1) and angiotensin II (AngII) receptor antagonism with
sparsentan has strong antiproteinuric actions via multiple potential mechanisms that are …