Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear
receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes …

Abstract Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …

Arginine methylation is a common posttranslational modification that governs important
cellular processes and impacts development, cell growth, proliferation, and differentiation …

The highly expressed oncogenic factor Krüppel‐like factor 5 (KLF5) promotes various
cancerous processes, such as cell growth, survival, anti‐apoptosis, migration and …

PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-
histone target proteins, is overexpressed and plays a pathogenic role in many cancers. In …

Nonalcoholic fatty liver disease (NAFLD) is a progressive condition that encompasses a
spectrum of liver disorders, beginning with the simple steatosis, progressing to nonalcoholic …

Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …

Emerging evidence shows that type II protein arginine methyltransferase 5 (PRMT5) serves
as an oncoprotein and plays a critical role in many types of human cancer. However, the …

Aims Individuals with nonalcoholic hepatosteatosis (NAFLD) have a worse atherogenic
lipoprotein profile and are susceptible to cardiovascular diseases. The MEK-ERK signaling …