This review paper explores the cutting-edge advancements in hydrogel design for articular
cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence …

Injury of articular cartilage due to trauma or pathological conditions is the major cause of
disability worldwide, especially in North America. The increasing number of patients …

Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …

Objective: Functional tissue engineering (FTE) of articular cartilage involves the use of
physiologically relevant mechanical signals to encourage the growth of engineered …

We developed an injectable hydrogel system to evaluate the effect of hydrogel stiffness on
chondrocyte cellular functions in a three-dimensional (3D) environment and its subsequent …

Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage
formation and functionality. It arises from mesenchymal stem cells (MSCs) and is regulated …

Despite an increasing burden of osteoarthritis in developed societies, target discovery has
been slow and there are currently no approved disease-modifying osteoarthritis drugs. This …

Agarose hydrogels are commonly used for cartilage tissue engineering studies and to
provide a three dimensional environment to investigate cellular mechanobiology …

Mesenchymal stem cells (MSCs) are an attractive cell source for cartilage tissue engineering
and regenerative medicine. However, the use of these cells has been limited by their …

BACKGROUND: For current tissue engineering or regenerative medicine strategies,
chondrocyte (CC)-or mesenchymal stem cell (MSC)-seeded constructs are typically cultured …