Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Although the introduction of tumor necrosis factor (TNF) inhibitors represented a significant
advance in the treatment of rheumatoid arthritis (RA), traditional anti-TNFα antibodies are …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death.
In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted …

The VEGF (vascular endothelial growth factor) family and its receptors are essential
regulators of angiogenesis and vascular permeability. Currently, the VEGF family consists of …

Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a
highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived …

Vascular endothelial growth factors and their endothelial tyrosine kinase receptors are
central regulators of vasculogenesis, angiogenesis and lymphangiogenesis. VEGF …

The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-
B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1,-2 and …

Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique
capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by …