Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress–Implications for cardiovascular and …

A Daiber, M Kuntic, O Hahad, LG Delogu… - Archives of biochemistry …, 2020 - Elsevier
Environmental pollution is a major cause of global mortality and burden of disease. All
chemical pollution forms together may be responsible for up to 12 million annual excess …

Mitochondria-targeted, nanoparticle-based drug-delivery systems: Therapeutics for mitochondrial disorders

S Buchke, M Sharma, A Bora, M Relekar, P Bhanu… - Life, 2022 - mdpi.com
Apart from ATP generation, mitochondria are involved in a wide range of functions, making
them one of the most prominent organelles of the human cell. Mitochondrial dysfunction is …

Bright near-infrared aggregation-induced emission luminogens with strong two-photon absorption, excellent organelle specificity, and efficient photodynamic therapy …

Z Zheng, T Zhang, H Liu, Y Chen, RTK Kwok, C Ma… - Acs Nano, 2018 - ACS Publications
Far-red and near-infrared (NIR) fluorescent materials possessing the characteristics of
strong two-photon absorption and aggregation-induced emission (AIE) as well as specific …

Nanoscale metal–organic layer isolates phthalocyanines for efficient mitochondria-targeted photodynamic therapy

GT Nash, T Luo, G Lan, K Ni… - Journal of the American …, 2021 - ACS Publications
Zinc-phthalocyanine (ZnPc) photosensitizers (PSs) have shown great potential in
photodynamic therapy (PDT) owing to their strong absorption at long wavelengths (650–750 …

Mitochondria targeted protein-ruthenium photosensitizer for efficient photodynamic applications

S Chakrabortty, BK Agrawalla, A Stumper… - Journal of the …, 2017 - ACS Publications
Organelle-targeted photosensitization represents a promising approach in photodynamic
therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we …

Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging

M Kowalska, T Piekut, M Prendecki, A Sodel… - DNA and cell …, 2020 - liebertpub.com
Mitochondria play an important role in numerous processes, including energy generation,
regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of …

Endocytosis and organelle targeting of nanomedicines in cancer therapy

X Wang, Y Qiu, M Wang, C Zhang, T Zhang… - International journal …, 2020 - Taylor & Francis
Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to
efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by …

Chemotherapy resistance explained through endoplasmic reticulum stress-dependent signaling

E Bahar, JY Kim, H Yoon - Cancers, 2019 - mdpi.com
Cancers cells have the ability to develop chemotherapy resistance, which is a persistent
problem during cancer treatment. Chemotherapy resistance develops through different …

Functional materials for subcellular targeting strategies in cancer therapy: progress and prospects

Y Cheng, Z Qu, Q Jiang, T Xu, H Zheng, P Ye… - Advanced …, 2023 - Wiley Online Library
Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Mitochondrial regulation of stem cells in bone homeostasis

CX Zheng, BD Sui, XY Qiu, CH Hu, Y Jin - Trends in Molecular Medicine, 2020 - cell.com
Mitochondria have emerged as key contributors to the organismal homeostasis, in which
mitochondrial regulation of stem cells is becoming increasingly important. Originated from …