The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …

Break-induced replication (BIR) is a pathway that repairs one-ended double-strand breaks
(DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic …

Flaws in the DNA replication process have emerged as a leading driver of genome
instability in human diseases. Alteration to replication fork progression is a defining feature …

Single-strand breaks (SSBs) are one of the most commonly occurring endogenous lesions
with the potential to give rise to cytotoxic double-strand breaks (DSBs) during DNA …

Nanomaterials have emerged as a promising strategy for enhancing secondary metabolites
and improving plants to tolerate abiotic stress. Environmental stressors like extreme …

Break-induced replication (BIR) repairs one-ended double-strand DNA breaks through
invasion into a homologous template followed by DNA synthesis. Different from S-phase …

The maintenance of genome integrity involves multiple independent DNA damage
avoidance and repair mechanisms. However, the origin and pathways of the focal …

Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR),
a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay …

DNA synthesis during homologous recombination is highly mutagenic and prone to template
switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene …

Alternative lengthening of telomeres (ALT) is a recombination process that maintains
telomeres in the absence of telomerase and helps cancer cells to survive. Yeast has been …