ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …

In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic
aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stress …

Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

RNA function relies heavily on posttranscriptional modifications. Recently, it was shown that
certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP …

Poly (ADP-ribose)(PAR) is a nucleic acid-like protein modification that can seed the
formation of microscopically visible cellular compartments that lack enveloping membranes …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several
families of RNA viruses and have recently been shown to counter innate immune responses …