Mesoporous silica-based nanoplatforms are theranostic agents for the treatment of inflammatory disorders

BS Sivamaruthi, S Thangaleela, P Kesika, N Suganthy… - Pharmaceutics, 2023 - mdpi.com
Complete recovery from infection, sepsis, injury, or trauma requires a vigorous response
called inflammation. Inflammatory responses are essential in balancing tissue homeostasis …

[HTML][HTML] Multistructured hydrogel promotes nerve regeneration

N Zhu, Y Zhuang, W Sun, J Wang, F Wang… - Materials Today …, 2024 - Elsevier
Hydrogels have emerged as promising biomaterials for nerve regeneration due to their
adjustable properties, structural resemblance to the extracellular matrix, and ability to …

[HTML][HTML] Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

P Yang, Y Peng, X Dai, J Jie, D Kong, X Gu, Y Yang - Bioactive Materials, 2023 - Elsevier
Tissue regeneration requires exogenous and endogenous signals, and there is increasing
evidence that the exogenous microenvironment may play an even more dominant role in the …

Bioactive mesoporous silica nanoparticle-functionalized titanium implants with controllable antimicrobial peptide release potentiate the regulation of inflammation and …

J Dong, F Chen, Y Yao, C Wu, S Ye, Z Ma, H Yuan… - Biomaterials, 2024 - Elsevier
Bacterial infection and delayed osseointegration are two major challenges for titanium-
based orthopedic implants. In the present study, we developed a functionalized titanium …

Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury

S Wang, R Wang, J Chen, B Yang, J Shu… - Journal of Controlled …, 2023 - Elsevier
Pharmaceutical treatments are critical for the acute and subacute phases of spinal cord
injury (SCI) and significantly impact patients' prognoses. However, there is a lack of a …

Bioactive Peptide Hydrogel Scaffold with High Fluidity, Thermosensitivity, and Neurotropism in 3D Spatial Structure for Promoted Repair of Spinal Cord Injury

Z Sun, X Luan, Z Sun, D Li, H Hu, Q Xue, B Liu, Q Yu… - Small, 2024 - Wiley Online Library
Spinal cord injury (SCI) has been considered a clinically challenging disease that is
characterized by local disturbance of the microenvironment, which inhibits post‐injury neural …

A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury

H Chen, W Wang, Y Yang, B Zhang, Z Li, L Chen, Q Tu… - Biomaterials, 2025 - Elsevier
Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising
strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to …

ROS: Executioner of regulating cell death in spinal cord injury

Z Yin, B Wan, G Gong, J Yin - Frontiers in Immunology, 2024 - frontiersin.org
The damage to the central nervous system and dysfunction of the body caused by spinal
cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by …

Reactive oxygen species-scavenging biomaterials for neural regenerative medicine

F Wei, W Yang, H Wang, S Song, Y Ji, Z Chen… - Biomaterials …, 2025 - pubs.rsc.org
Reactive oxygen species (ROS) are natural by-products of oxygen metabolism. As signaling
molecules, ROS can regulate various physiological processes in the body. However …

Advancing Recovery Post‐Spinal Cord Injury: Nanoparticle‐Mediated Reprogramming of Peripheral Macrophages

J Liu, D Liu, R Ma, Z Ma, Z Peng… - Advanced Functional …, 2024 - Wiley Online Library
Spinal cord injuries (SCIs) often result in secondary damage; therefore, interventions
beyond current cell transplantation methods must be explored. The innate phagocytic …