Plant derived products and phytoconstituents have been used in medicine for the treatment
of human disorders and associated secondary complication since a very early age …

Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …

Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized
via click chemistry, between different azide derivatives and substituted benzimidazole …

Abstract Nineteen 3, 5‐disubstituted‐isoxazole analogs were synthesized based on
nitrofuran scaffolds, by a [3+ 2] cycloaddition reaction between terminal acetylenes and 5 …

Chagas disease and leishmaniasis are neglected diseases of high priority as a public health
problem. Pharmacotherapy is based on the administration of a few drugs, which exhibit …

A series of 28 compounds, 3-nitro-1 H-1, 2, 4-triazole, were synthesized by click-chemistry
with diverse substitution patterns using medicinal chemistry approaches, such as …

This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of
their biological activity. Analogs 8–13 (L13-L18) exhibited anti-inflammatory activity …

Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for
type 2 diabetes. A series of novel 1, 2, 3-triazole based xanthine derivatives were designed …

In our search for soluble epoxide hydrolase (sEH) inhibitors from plants, we found that water
extracts of Scutellaria baicalensis Georgi displayed significant inhibitory activity against sEH …

Using bioisosterism as a medicinal chemistry tool, 16 3, 5‐diaryl‐isoxazole analogues of the
tetrahydrofuran neolignans veraguensin, grandisin and machilin G were synthesized via 1, 3 …