Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal
environment. Apoptosis is an initiative cell death process that is controlled by genes and is …

Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Objectives: Intervertebral disc degeneration (IDD) is widely accepted as a cause of low back
pain and related degenerative musculoskeletal disorders. Nucleus pulposus (NP) cell …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Mechanisms by which autophagy promotes cell survival or death are unclear. We provide
evidence that C18-pyridinium ceramide treatment or endogenous C18-ceramide generation …

Obesity has been implicated as a risk factor for insulin resistance and cardiovascular
diseases (CVDs). Although the association between obesity and CVD is a well-established …

Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …