Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Mitochondrial dysfunction is a key feature of injury to numerous tissues and stem cell aging.
Although the tissue regenerative role of mesenchymal stem cell (MSC)-derived extracellular …

Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Diabetes belongs to a group of metabolic disorders characterized by long term high blood
glucose levels due to either inadequate production of insulin (Type 1 diabetes, T1DM) or …

There is a growing body of evidence that links epigenetic modifications to type 2 diabetes.
Researchers have more recently investigated effects of commonly used medications …

Nanotechnology plays an undeniable significant role in medical sciences, particularly in the
field of biomedicine. Development of several diagnostic procedures in medicine has been …

Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …

Background Diabetic foot is caused by ischemic disease of lower extremities of diabetic
patients, and the effective therapy is very limited. Mesenchymal stem cells (MSCs) based …