Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions
DL Boger, J Desharnais… - Angewandte Chemie …, 2003 - Wiley Online Library
The high‐throughput synthesis and screening of compound libraries hold tremendous
promise for drug discovery and powerful methods for both solid‐phase and solution‐phase …
promise for drug discovery and powerful methods for both solid‐phase and solution‐phase …
Advances in DNA-ligands with groove binding, intercalating and/or alkylating activity: chemistry, DNA-binding and biology
U Pindur, M Jansen, T Lemster - Current medicinal chemistry, 2005 - ingentaconnect.com
It is known that DNA is a well-characterized intracellular target but its size and sequential
characteristics make it an elusive target for selective drug action. Binding of low molecular …
characteristics make it an elusive target for selective drug action. Binding of low molecular …
A highly selective and sensitive fluorescence probe for the hypochlorite anion
X Chen, X Wang, S Wang, W Shi… - … –A European Journal, 2008 - Wiley Online Library
A new rhodamine B‐based fluorescent probe for the hypochlorite anion (OCl−) has been
designed, synthesized, and characterized. The probe comprises a spectroscopic unit of …
designed, synthesized, and characterized. The probe comprises a spectroscopic unit of …
Pyrrolbenzodiazepines
DE Thurston, PW Howard - US Patent 7,049,311, 2006 - Google Patents
2017-04-11 Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
Total synthesis of distamycin A and 2640 analogues: a solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and …
DL Boger, BE Fink, MP Hedrick - Journal of the American …, 2000 - ACS Publications
The development of a solution-phase synthesis of distamycin A and its extension to the
preparation of 2640 analogues are described. Thus, solution-phase synthesis techniques …
preparation of 2640 analogues are described. Thus, solution-phase synthesis techniques …
Pyrrolobenzodiazepines
DE Thurston, PW Howard - US Patent 7,067,511, 2006 - Google Patents
2017-04-11 Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
CORRECTIVE ASSIGNMENT TO CORRECT THE POSTAL CODE OF THE ASSIGNEE …
Pyrrolobenzodiazepines
DE Thurston, PW Howard - US Patent 7,407,951, 2008 - Google Patents
3,523,941 A 8/1970 Leimgruber et al. 3,524,849 A 8, 1970 Batcho et al. 4,185,016 A 1, 1980
Takanabe et al. 4,239,683 A 12/1980 Takanabe et al. 4,309.437 A 1, 1982 Ueda et al …
Takanabe et al. 4,239,683 A 12/1980 Takanabe et al. 4,309.437 A 1, 1982 Ueda et al …
Synthesis of protected pyrrolobenzodiazepines
P Howard, L Masterson - US Patent 7,429,658, 2008 - Google Patents
US7429658B2 - Synthesis of protected pyrrolobenzodiazepines - Google Patents
US7429658B2 - Synthesis of protected pyrrolobenzodiazepines - Google Patents Synthesis of …
US7429658B2 - Synthesis of protected pyrrolobenzodiazepines - Google Patents Synthesis of …
Pyrrolobenzodiazepines
DE Thurston, PW Howard - US Patent 7,265,105, 2007 - Google Patents
4,309,437 A 1/1982 Ueda et al.................. 424/274 5,143,854 A 9/1992 Pirrung et al...
436/518 5,545,568 A 8/1996 Ellman et al... 436/518 6,562,806 B1 5/2003 Thurston et al …
436/518 5,545,568 A 8/1996 Ellman et al... 436/518 6,562,806 B1 5/2003 Thurston et al …
Conformationally restricted carbohydrate-modified nucleic acids and antisense technology
P Herdewijn - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1999 - Elsevier
The study of conformationally restricted carbohydrate modified nucleic acids has given new
insights into the concept of the antisense technology. We learned to understand the …
insights into the concept of the antisense technology. We learned to understand the …