Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Machine learning that generates biological hypotheses has transformative potential, but
most learning algorithms are susceptible to pathological failure when exploring regimes …

Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …

Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …

Most of the newly discovered compounds showing promise for the treatment of TB, notably
multidrug-resistant TB, inhibit aspects of Mycobacterium tuberculosis cell envelope …

In this review, we address some recent developments in the field of bacterial protein
phosphorylation, focusing specifically on serine/threonine and tyrosine kinases. We present …

All domains of life utilize protein phosphorylation as a mechanism of signal transduction. In
bacteria, protein phosphorylation was classically thought to be mediated exclusively by …

Obstacles to bacterial survival and replication in the cytosol of host cells, and the
mechanisms used by bacterial pathogens to adapt to this niche are not well understood …

Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …