Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
M Ito, Y Fujita, A Shinohara - DNA repair, 2023 - Elsevier
RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading
A Zainu, P Dupaigne, S Bouchouika, J Cau… - Nature …, 2024 - nature.com
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart
Q Zhang, J Fan, W Xu, H Cao, C Qiu… - Nucleic Acids …, 2023 - academic.oup.com
Recruitment of RAD51 and/or DMC1 recombinases to single-strand DNA is indispensable
for homology search and strand invasion in homologous recombination (HR) and for …
for homology search and strand invasion in homologous recombination (HR) and for …
Chromatin protein complexes involved in gene repression in lamina-associated domains
Lamina-associated domains (LADs) are large chromatin regions that are associated with the
nuclear lamina (NL) and form a repressive environment for transcription. The molecular …
nuclear lamina (NL) and form a repressive environment for transcription. The molecular …
Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions
X Zhang, Z Zhao, X Wang, S Zhang, Z Zhao… - Cell Death & …, 2024 - nature.com
Osteosarcoma is a malignant bone tumor that primarily inflicts the youth. It often
metastasizes to the lungs after chemotherapy failure, which eventually shortens patients' …
metastasizes to the lungs after chemotherapy failure, which eventually shortens patients' …
Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation
K Matsuzaki, A Shinohara… - Nucleic Acids Research, 2024 - academic.oup.com
RAD51 filament is crucial for the homology-dependent repair of DNA double-strand breaks
and stalled DNA replication fork protection. Positive and negative regulators control RAD51 …
and stalled DNA replication fork protection. Positive and negative regulators control RAD51 …
The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 …
A Zainu, P Dupaigne, S Bouchouika, J Cau… - bioRxiv, 2023 - biorxiv.org
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair
Interstrand DNA cross-links (ICLs) represent complex lesions that compromise genomic
stability. Several pathways have been involved in ICL repair, but the extent of factors …
stability. Several pathways have been involved in ICL repair, but the extent of factors …
FIRRM and FIGNL1: partners in the regulation of homologous recombination
S Tsaridou, MATM van Vugt - Trends in Genetics, 2024 - cell.com
DNA repair through homologous recombination (HR) is of vital importance for maintaining
genome stability and preventing tumorigenesis. RAD51 is the core component of HR …
genome stability and preventing tumorigenesis. RAD51 is the core component of HR …