Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor
cells, macrophages, osteoblasts and-clasts, and chondrocytes to restore the osseous tissue …

Osteoporosis-related fractures are a major public health problem. Mechanobiological
stimulation utilizing low-intensity pulsed ultrasound (LIPUS) is the most widely accepted …

Reconstructing critical-sized craniofacial bone defects is a global healthcare challenge.
Current methods, like autologous bone transplantation, face limitations. Bone tissue …

Bone fractures are a widespread clinical event due to accidental falls and trauma or bone
fragility; they also occur in association with various diseases and are common with aging. In …

Hypertrophic chondrocytes are found at unique locations at the junction of skeletal tissues,
cartilage growth plate, articular cartilage, enthesis and intervertebral discs. Their role in the …

Background: The healing of a bone injury is a highly complex process involving a multitude
of different tissue and cell types, including immune cells, which play a major role in the …

The development of hydroxyapatite (HAp) and polyether ether ketone (PEEK) biocomposites
has been extensively studied for bone repair applications due to the synergistic properties of …

Norisoboldine (NOR), the major isoquinoline alkaloid constituent of a Chinese traditional
medicine Radix Linderae, has been demonstrated to inhibit osteoclast differentiation and …

Fractures continue to be a global economic burden as there are currently no osteoanabolic
drugs approved to accelerate fracture healing. In this study, we aimed to develop an …

The repair of large cartilage defects remains highly challenging in the fields of orthopedics
and oral and maxillofacial surgery. A chondroinductive agent is promising to activate …