Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …

Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …

Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …

Background The role of ovulation in epithelial ovarian cancer (EOC) is supported by the
consistent protective effects of parity and oral contraceptive use. Whether these factors …

Breast, cervical and ovarian cancers are highly prevalent in women worldwide.
Environmental, hormonal and viral-related factors are especially relevant in the …

Elucidating the earliest pathogenic steps in cancer development is fundamental to improving
its early detection and prevention. Ovarian high-grade serous carcinoma (HGSC), a highly …

This review focuses on pathogenesis of endometriosis, its possible biomarkers and role in
endometriosis-associated ovarian cancer. We analyzed various databases to obtain new …

Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, and most
patients develop chemoresistance after first-line treatments. Despite recent advances, the 5 …

Background Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-
grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating …

Ovarian cancer is one of the most common causes of morbidity related to gynecologic
malignancies. Possible risk factors are including hereditary ovarian cancer, obesity …