International union of basic and clinical pharmacology. CI. Structures and small molecule modulators of mammalian adenylyl cyclases
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
KF Ostrom, JE LaVigne, TF Brust… - Physiological …, 2022 - journals.physiology.org
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
SM Cloonan, K Glass, ME Laucho-Contreras… - Nature medicine, 2016 - nature.com
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …
genetic determinants. We have previously identified iron-responsive element–binding …
Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep
YH Cao, SS Xu, M Shen, ZH Chen… - Molecular Biology …, 2021 - academic.oup.com
How animals, particularly livestock, adapt to various climates and environments over short
evolutionary time is of fundamental biological interest. Further, understanding the genetic …
evolutionary time is of fundamental biological interest. Further, understanding the genetic …
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
Gain‐of‐function ADCY5 mutations in familial dyskinesia with facial myokymia
YZ Chen, JR Friedman, DH Chen… - Annals of …, 2014 - Wiley Online Library
Objective To identify the cause of childhood onset involuntary paroxysmal choreiform and
dystonic movements in 2 unrelated sporadic cases and to investigate the functional effect of …
dystonic movements in 2 unrelated sporadic cases and to investigate the functional effect of …
The etiologic origins for chronic obstructive pulmonary disease
X Huang, X Mu, L Deng, A Fu, E Pu… - International journal of …, 2019 - Taylor & Francis
COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …
respiratory symptoms, has resulted in enormous challenges to human health worldwide …
The “iron”-y of iron overload and iron deficiency in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease
and the third leading cause of death worldwide (1). COPD is characterized by three major …
and the third leading cause of death worldwide (1). COPD is characterized by three major …
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
X Li, GA Hawkins, EJ Ampleford, WC Moore… - Journal of allergy and …, 2013 - Elsevier
Background Recent meta-analyses of genome-wide association studies in general
populations of European descent have identified 28 loci for lung function. Objective We …
populations of European descent have identified 28 loci for lung function. Objective We …