The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

The immune system's ability to resist the invasion of foreign pathogens and the tolerance to
self-antigens are primarily centered on the efficient functions of the various subsets of T …

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized
infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue …

Background The detection of physiologically relevant protein isoforms encoded by the
human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the …

Vagal sensory neurons monitor mechanical and chemical stimuli in the gastrointestinal tract.
Major efforts are underway to assign physiological functions to the many distinct subtypes of …

Lineage-determining transcription factors (LD-TFs) drive the differentiation of progenitor
cells into a specific lineage. In CD4+ T cells, T-bet dictates differentiation of the TH1 lineage …

In development, pioneer transcription factors access silent chromatin to reveal lineage-
specific gene programs. The structured DNA-binding domains of pioneer factors have been …

T cell activation, a key early event in the adaptive immune response, is subject to elaborate
transcriptional control. In the present study, we examined how the activities of eight major …

Runx factors are essential for lineage specification of various hematopoietic cells, including
T lymphocytes. However, they regulate context-specific genes and occupy distinct genomic …

T cells develop from multipotent progenitors by a gradual process dependent on intrathymic
Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell …