In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …

There is a pressing need to discover and develop novel drugs against cancer. With the new
era of bioinformatics, which integrates different aspects, drug development has been …

Worldwide, cancer is still an area with high unmet medical need. Lead optimization efforts
towards structure-based drug design were employed to discover newly synthesized hetero …

Background: Low-cost, high-throughput in vitro bioassays have potential as alternatives to
animal models for toxicity testing. However, incorporating in vitro bioassays into chemical …

Ancient humans used dietary plants and herbs to treat disease and to pursue eternal life.
Today, phytochemicals in dietary plants and herbs have been shown to be the active …

Background: Chalcones are naturally occurring compounds found in various plant species
which are widely used for the traditional popular treatments. Chalcones are distinguished …

Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …