[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

[PDF][PDF] Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

J May, JA Mitchell, RG Jenkins - Journal of Clinical …, 2023 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …

Emerging delivery approaches for targeted pulmonary fibrosis treatment

R Diwan, HN Bhatt, E Beaven, M Nurunnabi - Advanced drug delivery …, 2024 - Elsevier
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Molecular pathogenesis of pulmonary fibrosis, with focus on pathways related to TGF-β and the ubiquitin-proteasome pathway

N Inui, S Sakai, M Kitagawa - International journal of molecular sciences, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During
the past decade, novel pathogenic mechanisms of IPF have been elucidated that have …

Novel drug delivery systems and disease models for pulmonary fibrosis

R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …

Pro-and anti-fibrotic effects of vascular endothelial growth factor in chronic kidney diseases

C Miao, X Zhu, X Wei, M Long, L Jiang, C Li, D Jin… - Renal failure, 2022 - Taylor & Francis
Renal fibrosis is the inevitable common end-point of all progressive chronic kidney
diseases. The underlying mechanisms of renal fibrosis are complex, and currently there is …

Characterization of the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis using single-cell RNA sequencing

X Liu, X Qin, H Qin, C Jia, Y Yuan, T Sun, B Chen… - Angiogenesis, 2021 - Springer
The loss of normal alveolar capillary and deregulated angiogenesis occurs simultaneously
in idiopathic pulmonary fibrosis (IPF); however the contributions of specific endothelial …

[HTML][HTML] Macrophage-derived MMP12 promotes fibrosis through sustained damage to endothelial cells

X Zhou, C Zhang, S Yang, L Yang, W Luo… - Journal of Hazardous …, 2024 - Elsevier
Macrophages are essential for the maintenance of endothelial cell function. However, the
potential impact and mechanisms of crosstalk between macrophages and endothelial cells …

Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin

A Hosseinzadeh, SA Javad-Moosavi, RJ Reiter… - Life sciences, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive loss of lung function
due to tissue scarring. A variety of pro-inflammatory and pro-fibrogenic factors including …

Эндотелиальная дисфункция: от частного к общему. Возврат к «старой парадигме»?

ТД Власов, ИИ Нестерович… - Регионарное …, 2019 - microcirc.ru
Аннотация Сосудистый эндотелий представляет собой гетерогенную структуру,
обладающую многообразными функциями, являясь активной метаболической …