Anti-inflammatory mechanisms of dietary flavones: tapping into nature to control chronic inflammation in obesity and cancer

A Kariagina, AI Doseff - International Journal of Molecular Sciences, 2022 - mdpi.com
Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory
properties provide unique opportunities to control the innate immune system and …

Immunesenescence: a predisposing risk factor for the development of COVID-19?

J Hazeldine, JM Lord - Frontiers in immunology, 2020 - frontiersin.org
Bearing a strong resemblance to the phenotypic and functional remodeling of the immune
system that occurs during aging (termed immunesenescence), the immune response to …

The role of obesity and bariatric surgery-induced weight loss in breast cancer

MS Bohm, LM Sipe, ME Pye, MJ Davis… - Cancer and Metastasis …, 2022 - Springer
Obesity is a complex metabolic condition considered a worldwide public health crisis, and a
deeper mechanistic understanding of obesity-associated diseases is urgently needed …

Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets

Q Wu, W Zhang, Y Lu, H Li, Y Yang, F Geng… - International …, 2024 - Elsevier
Periodontitis, which is related to various systemic diseases, is a chronic inflammatory
disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the …

Emerging roles of myeloid-derived suppressor cells in diabetes

S Wang, Q Tan, Y Hou, H Dou - Frontiers in Pharmacology, 2021 - frontiersin.org
Diabetes is a syndrome characterized by hyperglycemia with or without insulin resistance.
Its etiology is attributed to the combined action of genes, environment and immune cells …

Microbiota‐immune‐brain interactions: A new vision in the understanding of periodontal health and disease

TJ Breivik, P Gjermo, Y Gundersen… - Periodontology …, 2024 - Wiley Online Library
This review highlights the significance of interactions between the microbiota, immune
system, nervous and hormonal systems, and the brain on periodontal health and disease …

Type 2 diabetes mellitus metabolic control correlates with the phenotype of human monocytes and monocyte-derived macrophages

MA Valtierra-Alvarado, JEC Delgado… - Journal of Diabetes and …, 2020 - Elsevier
Aims Monocytes and macrophages express cell-surface markers indicative of their
inflammatory and activation status. In this study, we investigated whether these markers are …

Identification and verification of immune-related biomarkers and immune infiltration in diabetic heart failure

Z Zhong, H Zhang, T Xu, J Hao, X Chen… - Frontiers in …, 2022 - frontiersin.org
Purpose Diabetic heart failure (DHF) or cardiomyopathy is a common complication of
diabetes; however, the underlying mechanism is not clear. In the present study, the authors …

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

Y Li, Y Xu, X Liu, X Yan, Y Lin, Q Tan, Y Hou - Stem cell research & …, 2021 - Springer
Background Skin wounds in diabetic patients hardly recover. Accumulating evidence has
shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived …

[HTML][HTML] Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 …

SH Murch - Medical hypotheses, 2020 - Elsevier
SARS-CoV-2 interaction with the ACE-2 receptor cannot alone explain the demography and
remarkable variation in clinical progression of Covid-19 infection. Unlike SARS-CoV, the …