The formation of C–aryl bonds has been the focus of intensive research over the last
decades for the construction of complex molecules from simple, readily available feedstocks …

Carbon–sulfur bond cross-coupling has become more and more attractive as an alternative
protocol to establish carbon–carbon and carbon–heteroatom bonds. Diverse …

At the advent of cross-coupling chemistry, carbon electrophiles based on halides or
pseudohalides were the only suitable electrophilic coupling partners. Almost two decades …

Conspectus Synthetic chemists have consistently aimed to develop efficient methods for
synthesizing ketones, which are essential building blocks in organic chemistry and play …

Small molecules that modulate the 14-3-3 protein–protein interaction (PPI) network
represent valuable therapeutics and tool compounds. However, access has been lost to 14 …

Transition-metal-catalyzed cross-coupling reactions of thioesters by selective acyl C (O)–S
cleavage have emerged as a powerful platform for the preparation of complex molecules …

Alkenes bearing four carbon-based groups are ubiquitous motifs in chemical sciences due
to their various applications from medicinal to materials chemistry, and as chemical …

The direct modification of naturally occurring chiral amino acids to their amino ketone
analogs is a significant synthetic challenge. Here, an efficient and robust cross-coupling …

Isocyanides have long been known as versatile chemical reagents in organic synthesis.
Their ambivalent nature also allows them to function as a CO-substitute in palladium …

Organoboron compounds are well known building blocks for many organic reactions.
However, under basic conditions, polyfluorinated aryl boronic acid derivatives suffer from …