Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Antibacterial contact-dependent proteins secreted by Gram-negative cystic fibrosis respiratory pathogens

CV Crisan, JB Goldberg - Trends in microbiology, 2022 - cell.com
Cystic fibrosis (CF) is a genetic disease that affects almost 100 000 people worldwide. CF
patients suffer from chronic bacterial airway infections that are often polymicrobial and are …

Streptomyces umbrella toxin particles block hyphal growth of competing species

Q Zhao, S Bertolli, YJ Park, Y Tan, KJ Cutler, P Srinivas… - Nature, 2024 - nature.com
Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically
utilized antibiotics derive. The production of these antibacterial molecules reflects the …

Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation

S Vaidya, D Saha, DKH Rode, G Torrens… - Nature …, 2025 - nature.com
For any organism, survival is enhanced by the ability to sense and respond to threats in
advance. For bacteria, danger sensing among kin cells has been observed, but the …

Multiplicity of type 6 secretion system toxins limits the evolution of resistance

WPJ Smith, E Armstrong-Bond, KZ Coyte… - Proceedings of the …, 2025 - pnas.org
The bacterial type 6 secretion system (T6SS) is a toxin-injecting nanoweapon that mediates
competition in plant-and animal-associated microbial communities. Bacteria can evolve de …

Mechanisms of bacterial immunity, protection, and survival during interbacterial warfare

NW Kennedy, LE Comstock - Cell Host & Microbe, 2024 - cell.com
Most bacteria live in communities, often with closely related strains and species with whom
they must compete for space and resources. Consequently, bacteria have acquired or …

Trade-offs constrain adaptive pathways to type VI secretion system survival

KA MacGillivray, SL Ng, S Wiesenfeld, RL Guest… - Iscience, 2023 - cell.com
Summary The Type VI Secretion System (T6SS) is a nano-harpoon used by many bacteria
to inject toxins into neighboring cells. While much is understood about mechanisms of T6SS …

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

LN Yaeger, S French, ED Brown, JP Côté… - Plos Genetics, 2023 - journals.plos.org
Exposure of Escherichia coli to sub-inhibitory antibiotics stimulates biofilm formation through
poorly characterized mechanisms. Using a high-throughput Congo Red binding assay to …

Mechanisms of Pseudomonas aeruginosa resistance to Type VI Secretion System attacks

A Tejada-Arranz, A Plack, M Antelo-Varela… - bioRxiv, 2024 - biorxiv.org
The Type VI Secretion Systems (T6SSs) is a molecular nanomachine that injects toxic
effector proteins into the environment or neighbouring cells, and thus plays an important role …

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

Q Zhao, S Bertolli, YJ Park, Y Tan, KJ Cutler, P Srinivas… - bioRxiv, 2023 - biorxiv.org
The Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically
utilized antibiotics derive. The production of these antibacterial molecules reflects the …