Chronic kidney disease (CKD) is associated with the development of mineral bone disorder
(MBD), osteoporosis, and fragility fractures. Among CKD patients, adynamic bone disease or …

Chronic kidney disease (CKD) is a complex and multifactorial disease, and one of the most
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …

Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong
predictor of mortality in dialysis patients. FGF23 is thought to be an early biomarker of …

The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

Secondary hyperparathyroidism (SHPT) is a challenge frequently encountered in the
management of patients with chronic kidney disease (CKD). Downregulation of the …

Background—Klotho is known to function as a cofactor for the phosphatonin, fibroblast
growth factor (FGF)-23 at the kidney. FGF-23 levels rise in chronic kidney disease (CKD) …

Results The results indicated that 1 week of a vegetarian diet led to lower serum phosphorus
levels and decreased FGF23 levels. The inpatient stay demonstrated similar diurnal …

Chronic kidney disease (CKD) is a public health epidemic that affects millions of people
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within
kidney cells are not well understood. One candidate effector is Klotho, a protein expressed …