Polymer‐based mRNA delivery strategies for advanced therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery

B Sun, W Wu, EA Narasipura, Y Ma, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

The challenge and prospect of mRNA therapeutics landscape

Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Tools for translation: non-viral materials for therapeutic mRNA delivery

KA Hajj, KA Whitehead - Nature Reviews Materials, 2017 - nature.com
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …

Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation

W Gu, F Meng, R Haag, Z Zhong - Journal of controlled release, 2021 - Elsevier
The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …

Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery

Q Saiding, Z Zhang, S Chen, F Xiao, Y Chen… - Advanced Drug Delivery …, 2023 - Elsevier
Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …

Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Advances in mRNA non-viral delivery approaches

ML Ibba, G Ciccone, CL Esposito, S Catuogno… - Advanced drug delivery …, 2021 - Elsevier
Messenger RNAs (mRNAs) present a great potential as therapeutics for the treatment and
prevention of a wide range of human pathologies, allowing for protein replacement …

mRNA Delivery by a pH‐Responsive DNA Nano‐Hydrogel

X Fu, T Chen, Y Song, C Feng, H Chen, Q Zhang… - Small, 2021 - Wiley Online Library
The delivery of mRNA to manipulate protein expression has attracted widespread attention,
since that mRNA overcomes the problem of infection and mutation risks in transgenes and …