Persistent organic pollutants promote aggressiveness in prostate cancer
J Buñay, M Kossai, C Damon-Soubeyrant, A De Haze… - Oncogene, 2023 - nature.com
Increasing evidence points towards a causal link between exposure to persistent organic
pollutants (POPs) with increased incidence and aggressivity of various cancers. Among …
pollutants (POPs) with increased incidence and aggressivity of various cancers. Among …
Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …
Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice …
contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice …
Generative modeling of single-cell gene expression for dose-dependent chemical perturbations
Single-cell sequencing reveals the heterogeneity of cellular response to chemical
perturbations. However, testing all relevant combinations of cell types, chemicals, and doses …
perturbations. However, testing all relevant combinations of cell types, chemicals, and doses …
Influence of time-dependent sampling on the plasma metabolome and exposome of fish collected from an effluent-dependent pond
J Giebułtowicz, K Grabicová, BW Brooks… - Science of The Total …, 2024 - Elsevier
Metabolomics is increasingly recognized as a useful approach to characterize
environmental pollution gradients. While the performance of analytical procedures must be …
environmental pollution gradients. While the performance of analytical procedures must be …
Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate buildup
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that
induces diverse biological and toxic effects, including reprogramming intermediate …
induces diverse biological and toxic effects, including reprogramming intermediate …
Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the …
RR Fling, TR Zacharewski - International Journal of Molecular Sciences, 2021 - mdpi.com
Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated
with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype …
with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype …
Cystine/Glutamate Xc– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure …
Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has been associated with the
induction of oxidative stress and the progression of steatosis to steatohepatitis with fibrosis. It …
induction of oxidative stress and the progression of steatosis to steatohepatitis with fibrosis. It …
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway
Y Cong, Y Hong, D Wang, P Cheng… - Toxicological …, 2023 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is widely considered as the most
toxic and common carcinogen in the world. Exposure to TCDD causes liver lipid metabolism …
toxic and common carcinogen in the world. Exposure to TCDD causes liver lipid metabolism …
Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure
GN Cholico, R Nault, T Zacharewski - BMC genomics, 2024 - Springer
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant that disrupts hepatic function leading to steatotic liver disease (SLD)-like …
contaminant that disrupts hepatic function leading to steatotic liver disease (SLD)-like …