Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the
production of pathogenic autoantibodies. It has been postulated that gut microbial dysbiosis …

Integrating multiomics datasets is critical for microbiome research; however, inferring
interactions across omics datasets has multiple statistical challenges. We solve this problem …

Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that
predominantly affects preterm infants and is driven by poorly characterized inflammatory …

Background & Aims The down-regulated in adenoma (DRA) protein, encoded by SLC26A3,
a key intestinal chloride anion exchanger, has recently been identified as a novel …

Sporadic colorectal cancer is one of the most common and lethal cancers worldwide. The
locations and functions of immune cells in the colorectal tumor microenvironment are …

With the development of high-throughput DNA sequencing and molecular analysis
technologies, next-generation probiotics (NGPs) are increasingly gaining attention as live …

Deprivation of vitamin B12 (VB12) is linked to various diseases, but the underlying
mechanisms in disease progression are poorly understood. Using multiomic approaches …

Background Preterm birth is the leading cause of death in children under the age of five.
One of the major factors contributing to the high risk of diseases and deaths in premature …