Role of miRNA dysregulation in sepsis

A Formosa, P Turgeon, CC Dos Santos - Molecular Medicine, 2022 - Springer
Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a
dysregulated host response to infection and causes millions of deaths worldwide annually …

Modes of action and diagnostic value of miRNAs in sepsis

N Antonakos, C Gilbert, C Theroude… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting
in life-threatening organ dysfunction. Sepsis is a major public health concern associated …

Regulatory role of non-coding RNAs on immune responses during sepsis

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Frontiers in …, 2021 - frontiersin.org
Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents.
The induced inflammatory response by these microorganisms can lead to multiple organ …

Diagnostic significance of microRNAs in sepsis

X Zheng, Y Zhang, S Lin, Y Li, Y Hua, K Zhou - Plos one, 2023 - journals.plos.org
Background Sepsis is a life-threatening condition that induce tens of million death each
year, yet early diagnosis remains a formidable challenge. Many studies have focused on the …

Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis

X Shen, J Zhang, Y Huang, J Tong, L Zhang… - Journal of intensive …, 2020 - Springer
Objectives The aim of this study was to systematically assess the accuracy of circulating
microRNAs (miRNAs) as a promising biomarker for sepsis via a meta-analysis. Methods …

Clinical application of non-coding RNAs in sepsis

MA Iro, SPS Pandi - Current Opinion in Infectious Diseases, 2020 - journals.lww.com
Clinical applications of miRNAs and lncRNAs in sepsis are on the horizon. These data could
lead to the identification of novel treatments or indeed support the repurposing of existing …

Berberine attenuates neonatal sepsis in mice by inhibiting FOXA1 and NF-κB signal transduction via the induction of MiR-132-3p

B Li, S Niu, H Geng, C Yang, C Zhao - Inflammation, 2021 - Springer
Neonatal sepsis (NS) is a severe syndrome in newborns that is induced by infections, and
the initiation and development of NS are closely associated with the function of miRs. In the …

Multilevel omics for the discovery of biomarkers in pediatric sepsis

X Wang, R Li, S Qian, D Yu - Pediatric Investigation, 2023 - Wiley Online Library
Severe sepsis causes organ dysfunction and continues to be the leading reason for
pediatric death worldwide. Early recognition of sepsis could substantially promote precision …

[HTML][HTML] MicroRNAs in Sepsis

A Valsamaki, V Vazgiourakis, K Mantzarlis… - Biomedicines, 2024 - mdpi.com
Sepsis is an insidious and frequent condition of severe inflammation due to infections.
Several biomarkers have been established for initial screening, but the non-specific nature …

MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5

Y Lin, L Ma, H Dan, G Chen, J Dai, L Xu… - Journal of Surgical …, 2023 - Elsevier
Introduction Endothelial injury is a major characteristic of sepsis and contributes to sepsis-
induced multiple-organ dysfunction. In this study, we investigated the role of miR-107-3p in …