Sensitivity analysis of oscillator models in the space of phase-response curves: Oscillators as open systems

P Sacre, R Sepulchre - IEEE Control Systems Magazine, 2014 - ieeexplore.ieee.org
Oscillator models-whose steady-state behavior is periodic rather than constant-are
fundamental to rhythmic modeling, and they appear in many areas of engineering, physics …

An energy-optimal approach for entrainment of uncertain circadian oscillators

D Wilson, J Moehlis - Biophysical journal, 2014 - cell.com
We develop an approach to find an energy-optimal stimulus that entrains an ensemble of
uncertain, uncoupled limit cycle oscillators. Furthermore, when entrainment occurs, the …

Enhanced entrainability of genetic oscillators by period mismatch

Y Hasegawa, M Arita - Journal of The Royal Society …, 2013 - royalsocietypublishing.org
Biological oscillators coordinate individual cellular components so that they function
coherently and collectively. They are typically composed of multiple feedback loops, and …

On the dichotomic collective behaviors of large populations of pulse-coupled firing oscillators

A Mauroy - 2011 - orbi.uliege.be
The study of populations of pulse-coupled firing oscillators is a general and simple paradigm
to investigate a wealth of natural phenomena, including the collective behaviors of neurons …

Systems analysis of oscillator models in the space of phase response curves

P Sacré - 2013 - orbi.uliege.be
Oscillators---whose steady-state behavior is periodic rather than constant---are observed in
every field of science. While they have been studied for a long time as closed systems, they …

Sensitivity analysis of circadian entrainment in the space of phase response curves

P Sacré, R Sepulchre - A Systems Theoretic Approach to Systems and …, 2014 - Springer
Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given
parameter in a given system characteristic. Because the phase response curve is a …

Quantitative analysis of robustness in systems biology: Combining global and local approaches

M Hafner - 2010 - infoscience.epfl.ch
To characterize the behavior and robustness of cellular circuits is a major challenge for
Systems Biology. Many of the published methods that address this question quantify the …