Permeability Benchmarking: Guidelines for Comparing in Silico, in Vitro, and in Vivo Measurements
Permeability is a measure of the degree to which cells can transport molecules across
biological barriers. Units of permeability are distance per unit time (typically cm/s), where …
biological barriers. Units of permeability are distance per unit time (typically cm/s), where …
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
NM Dvorak, PA Wadsworth, G Aquino-Miranda… - Nature …, 2025 - nature.com
Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …
Modeling Substrate Entry into the P-Glycoprotein Efflux Pump at the Blood–Brain Barrier
C Jorgensen, MB Ulmschneider… - Journal of medicinal …, 2023 - ACS Publications
We report molecular dynamics simulations of rhodamine entry into the central binding cavity
of P-gp in the inward open conformation. Rhodamine can enter the inner volume via passive …
of P-gp in the inward open conformation. Rhodamine can enter the inner volume via passive …
Inorganic Nanoparticles for Brain Targeting Scope and Limitations
The drug delivery to the brain on systemic administration creates hindrance because of the
presence of blood–brain barrier (BBB). The utilization of novel nanomaterials such as …
presence of blood–brain barrier (BBB). The utilization of novel nanomaterials such as …