IMI–myopia genetics report

MS Tedja, AEG Haarman… - … & visual science, 2019 - iovs.arvojournals.org
IMI – Myopia Genetics Report | IOVS | ARVO Journals iovs Issues Topics For Authors About
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[HTML][HTML] An overview of myopia genetics

XB Cai, SR Shen, DF Chen, Q Zhang, ZB Jin - Experimental eye research, 2019 - Elsevier
Myopia is one of the leading ocular disorders causing visual impairment worldwide, with the
prevalence increasing rapidly. It's a significant global public health concern in 21st century …

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

MS Tedja, R Wojciechowski, PG Hysi, N Eriksson… - Nature …, 2018 - nature.com
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an
increasingly common cause of blindness. This genome-wide association meta-analysis in …

GRASP: analysis of genotype–phenotype results from 1390 genome-wide association studies and corresponding open access database

R Leslie, CJ O'Donnell, AD Johnson - Bioinformatics, 2014 - academic.oup.com
We created a deeply extracted and annotated database of genome-wide association studies
(GWAS) results. GRASP v1. 0 contains> 6.2 million SNP-phenotype association from among …

Myopia genetics and heredity

YM Wang, SY Lu, XJ Zhang, LJ Chen, CP Pang… - Children, 2022 - mdpi.com
Myopia is the most common eye condition leading to visual impairment and is greatly
influenced by genetics. Over the last two decades, more than 400 associated gene loci have …

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

NA Afshari, RP Igo Jr, NJ Morris, D Stambolian… - Nature …, 2017 - nature.com
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal
organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial …

Developmental regulation of RNA processing by Rbfox proteins

JG Conboy - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
The Rbfox genes encode an ancient family of sequence‐specific RNA binding proteins
(RBPs) that are critical developmental regulators in multiple tissues including skeletal …

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

Q Fan, X Guo, JWL Tideman, KM Williams, S Yazar… - Scientific reports, 2016 - nature.com
Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual
impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci …

Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia

R Clark, A Pozarickij, PG Hysi, K Ohno-Matsui… - PLoS …, 2022 - journals.plos.org
Myopia most often develops during school age, with the highest incidence in countries with
intensive education systems. Interactions between genetic variants and educational …

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

M Miyake, K Yamashiro, Y Tabara, K Suda… - Nature …, 2015 - nature.com
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide
association study for three myopia-related traits in 9,804 Japanese individuals, which was …