Toll-like receptor (TLR) signaling represents one of the best studied pathways to implement
defense mechanisms against invading microbes in human being as well as in animals …

Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

Contact lenses represent a widely utilized form of vision correction with more than 140
million wearers worldwide. Although generally well-tolerated, contact lenses can cause …

Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Nearly 20% of people affected by the herpes simplex virus (HSV) suffer from vision
problems. The virus can infect all layers of the cornea or cause inflammatory diseases of the …

Ocular inflammation is one of the most common comorbidities associated to ophthalmic
surgeries and disorders. Since conventional topical ophthalmic treatments present …

Purpose: Isorhamnetin is a natural flavonoid with both antimicrobial and anti-inflammatory
properties, but its effect on fungal keratitis (FK) remains unknown. The current study aims to …

Purpose Fungal keratitis is a sight-threatening corneal infection caused by fungal
pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this …

Tacrolimus has shown efficacy in eye inflammatory diseases. However, due to the drug
lability, its formulation into a stable ophthalmic product remains a challenge. Tacrolimus …

Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure
comprising:(i) the chitosan solution was air-dried to form a chitosan (CS) film,(ii) using citric …