This review examines the role of model-informed drug development (MIDD) in advancing
antibacterial and antiviral drug development, with an emphasis on the inclusion of host …

The emergence of antibiotic drug resistance has undermined the efficacy of antibiotics, and
is becoming a severe threat to public health. To combat antibiotic drug resistance and to …

Antibiotic usage in hospitals is considered the major driver of the emergence of antibiotic
resistance where selection of multiply resistant strains is most common. However, massive …

A model examining the population dynamics of susceptible bacteria, resistant bacteria,
adaptive immunity cells and innate cells in an infected individual receiving multiple …

Introduction Antimicrobial resistance (AMR) is a complex problem that requires the One
Health approach, that is, a collaboration among various disciplines working in different …

Integrated fish-duck pond is a common circular farming model in South China, besides, it is
also hot-spot for the co-selection of antibiotic resistance genes (ARGs). The aim of this study …

We formulate a system of ordinary differential equations to model the contribution of
antibiotic treatment and immune system to combat bacterial infections. We obtained …

In this paper, a mathematical model is developed to study bacterial resistance caused by
plasmids and mutations in the presence of the impulsive drug treatment. Firstly, the stability …

Here we present a prognostic model of horizontal spread of bacterial drug resistance genes
in spacecraft crews. The model takes into account the value of gene transfer frequency …

Bacterial plasmids play a fundamental role in antibiotic resistance. However, a lack of
knowledge about their biology is an obstacle in fully understanding the mechanisms and …